CP-809101 hydrochloride

Research use only, not for human use.

CP-809101 hydrochloride is a potent and selective 5-HT2C receptor agonist (pEC50: 9.96/7.19/6.81 for human 5-HT2C/5-HT2B/5-HT2A receptors).

CP-809101 hydrochloride is a potent and selective 5-HT2C receptor agonist (pEC50: 9.96/7.19/6.81 for human 5-HT2C/5-HT2B/5-HT2A receptors).(In Vitro):CP-809101 is a potent, functionally selective 5-HT2C agonist that displays approximately 100% efficacy in vitro.(In Vivo):Similar to currently available antipsychotic drugs, CP-809101 dose-dependently inhibited conditioned avoidance responding (CAR, ED50 = 4.8 mg/kg, sc). CP-809101 antagonized both PCP- and d-amphetamine-induced hyperactivity with ED50 values of 2.4 and 2.9 mg/kg (sc), respectively, and also reversed an apomorphine induced-deficit in prepulse inhibition. At doses up to 56 mg/kg, CP-809101 did not produce catalepsy. CP-809101 was inactive in two animal models of antidepressant-like activity, the forced swim test, and learned helplessness.

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Endocrinology/Hormones

5-HT Receptor

NMDA

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1215721-40-6

341.2

C15H18Cl2N4O

>98% (HPLC)

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Cl.Clc1cccc(COc2cncc(n2)N2CCNCC2)c1

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(-20℃)

With Ice Pack

≥ 2 years